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Indian Journal of Pharmacology
Medknow Publications on behalf of Indian Pharmacological Society
ISSN: 0253-7613 EISSN: 0253-7613
Vol. 41, No. 2, 2009, pp. 87-88
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Bioline Code: ph09024
Full paper language: English
Document type: Research Article
Document available free of charge
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Indian Journal of Pharmacology, Vol. 41, No. 2, 2009, pp. 87-88
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Studies on anti-inflammatory effect of aqueous extract of leaves of Holoptelea integrifolia , Planch. in rats
Sharma, Shrinivas; Lakshmi, KS; Patidar, Arjun; Chaudhary, Abhinav & Dhaker, Sanjay
Abstract
Objectives: The purpose of the present study was to investigate the anti-inflammatory properties of aqueous extract of the leaves of H. integrifolia, Planch.
Materials and Methods: The hind paw edema was produced in rats by subplanter injection of carageenan. The aqueous extract of H. integrifolia, Planch. (AHI) at dose (250 and 500 mg/kg p.o) was given to observe % inhibition of paw edema which were comparable with indomethacin (10 mg/kg p.o) used as a reference drug.
Results: The extract administered orally at doses of 250 and 500 mglkg p.o produced a significant (P < 0.05) dose dependent inhibition of edema formation
Conclusions: A significant % inhibition of paw edema by the aqueous extract of leaves of H. integrifolia, Planch. and its almost nearby same % inhibition with indomethacin suggest its usefulness as an anti-inflammatory agent.
Keywords
Antiinflammatory activity, Holoptelea integrifolia edema
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© Copyright 2009 Indian Journal of Pharmacology. Alternative site location: http://www.ijp-online.com
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