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Indian Journal of Pharmacology
Medknow Publications on behalf of Indian Pharmacological Society
ISSN: 0253-7613 EISSN: 0253-7613
Vol. 42, No. 5, 2010, pp. 324-325
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Bioline Code: ph10094
Full paper language: English
Document type: Special Article
Document available free of charge
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Indian Journal of Pharmacology, Vol. 42, No. 5, 2010, pp. 324-325
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Atorvastatin-induced pancreatitis
Prajapati, Samir; Shah, Samidh; Desai, Chetna; Desai, Mira & Dikshit, R. K.
Abstract
Drugs account for 1-2% of all cases of pancreatitis. A 58-year-old man was prescribed atorvastatin 10 mg for 6 months for hyperlipidemia. He developed acute abdominal pain and vomiting with epigastric tenderness. Serum lipase and CT scan of the patient suggested the presence of acute pancreatitis. The patient was hospitalized; atorvastatin was stopped and treated symptomatically. He recovered completely within 10 days of drug withdrawal. The causality of the adverse drug reaction according to Naranjo and WHO-UMC Scale was probable. The exact mechanism of pancreatitis due to atorvastatin is not known. It may be a class effect of HMG CoA reductase inhibitors as it had been reported with other statins too. The definite causal relationship is difficult to establish, as rechallenge with the suspected drug was not done due to ethical consideration.
Keywords
Adverse drug reaction, atorvastatin, pancreatitis
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© Copyright 2010 Indian Journal of Pharmacology. Alternative site location: http://www.ijp-online.com
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