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Indian Journal of Pharmacology
Medknow Publications on behalf of Indian Pharmacological Society
ISSN: 0253-7613 EISSN: 0253-7613
Vol. 42, No. 6, 2010, pp. 409-411
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Bioline Code: ph10117
Full paper language: English
Document type: Short Communication
Document available free of charge
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Indian Journal of Pharmacology, Vol. 42, No. 6, 2010, pp. 409-411
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Screening of anti-inflammatory and antipyretic activity of Vitex leucoxylon Linn
Shukla, Padmini; Shukla, P.; Mishra, S. B. & Gopalakrishna, B.
Abstract
Objective: This study was designed to evaluate the anti-inflammatory and antipyretic activity of ethyl acetate extract of Vitex leucoxylon Linn. in various animal experimental models.
Materials and Methods: Ethyl acetate extract of V. leucoxylon Linn. evaluated for anti-inflammatory activity in carrageenan, mediator-induced rat paw edema, and cotton pellet-induced granuloma model. The antipyretic activity was evaluated by yeast-induced pyrexia model.
Results: Single administration of the ethyl acetate extract of V. leucoxylon Linn. at dose of 500 mg/kg p.o. showed significant (P < 0.001) inhibition of rat paw edema. The ethyl acetate extract showed significant antipyretic activity in brewer yeast-induced pyrexia in rats throughout the observation period of 4 h.
Conclusion: This study shows that ethyl acetate extract of V. leucoxylon Linn. has significant anti-inflammatory and antipyretic activity.
Keywords
Inflammation, pyrexia, Vitex leucoxylon
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© Copyright 2010 Indian Journal of Pharmacology. Alternative site location: http://www.ijp-online.com
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