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Indian Journal of Pharmacology
Medknow Publications on behalf of Indian Pharmacological Society
ISSN: 0253-7613 EISSN: 0253-7613
Vol. 43, No. 4, 2011, pp. 463-465
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Bioline Code: ph11122
Full paper language: English
Document type: Short Communication
Document available free of charge
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Indian Journal of Pharmacology, Vol. 43, No. 4, 2011, pp. 463-465
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A comparative study of efficacy and safety of arformoterol and salbutamol nebulization as rescue therapy in acute non-severe asthma
Das, Sibes K.; Biswas, Indranil; Bandyopadhyay, Arun K.; Bairagya, Tapan D. & Bhattacharya, Somnath
Abstract
Arformoterol, a long-acting beta-2 agonist, has a rapid onset and long duration of action. Its role as rescue medication in acute asthma attack is undetermined. To compare the efficacy and tolerability of arformoterol with salbutamol nebulization, a study was conducted among 50 patients with acute non-severe asthma. Patients were randomly assigned to group 1 (n = 25) and group 2 (n = 25) who received three doses of salbutamol and arformoterol nebulization, respectively, at 20-min intervals. The peak expiratory flow rate (PEFR) was measured at the baseline and 5 min after each dose. The demographics and baseline characteristics were comparable between the two groups. The mean PEFR significantly increased in both these groups when compared with the baseline. The increases in the PEFR in two groups were similar after the third dose. The adverse effects in both these groups were minor. Arformoterol was as effective and safe as salbutamol in acute non-severe asthma.
Keywords
Acute asthma, arformoterol, bronchodilator, relief medication, salbutamol
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© Copyright 2011 Indian Journal of Pharmacology. Alternative site location: http://www.ijp-online.com
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