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Indian Journal of Pharmacology
Medknow Publications on behalf of Indian Pharmacological Society
ISSN: 0253-7613
EISSN: 0253-7613
Vol. 43, No. 4, 2011, pp. 469-471
Bioline Code: ph11124
Full paper language: English
Document type: Special Article
Document available free of charge

Indian Journal of Pharmacology, Vol. 43, No. 4, 2011, pp. 469-471

 en High anion gap refractory metabolic acidosis as a critical presentation of endosulfan poisoning
Sharma, Raj Kumar; Kaul, Anupama; Gupta, Anurag; Bhadauria, Dharmendra; Prasad, Narayan; Jain, Apoorva; Gurjar, M. & Rao, Bhaskar P.

Abstract

Organochloride insecticides are chlorinated cyclic hydrocarbons. One of such insecticides is endosulfan (6,7,8,9,10-10 hexachloro 1,5,5a,6,9,9a-hexahydro-6-methano-2,4,3-hexadithioxanthiep in 3-oxide) and it has been widely used in agriculture since 1960. The uncontrolled use of these compounds in developing countries has resulted in the deaths of animals and humans. Characteristic clinical signs following acute exposure are indicative of CNS disturbances or overstimulation. Mortality and morbidity rates are high and there is no specific antidote. We present an uncommon presentation of endosulfan poisoning in a 32-year-old male with high anion gap severe refractory metabolic acidosis. The patient was treated with continuous renal replacement therapy and was salvaged. Till date, there is no case report from India for endosulfan poisoning with severe metabolic acidosis and hypotension. Through this case report, we emphasize the role of continuous renal replacement therapy as a rescue therapy for endosulfan poisoning with severe refractory metabolic acidosis and hypotension, even though it is a non dialyzable poison.

Keywords
Continuous renal replacement therapy, endosulfan, metabolic acidosis

 
© Copyright 2011 Indian Journal of Pharmacology.
Alternative site location: http://www.ijp-online.com

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