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Indian Journal of Pharmacology
Medknow Publications on behalf of Indian Pharmacological Society
ISSN: 0253-7613 EISSN: 0253-7613
Vol. 43, No. 5, 2011, pp. 591-595
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Bioline Code: ph11155
Full paper language: English
Document type: Short Communication
Document available free of charge
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Indian Journal of Pharmacology, Vol. 43, No. 5, 2011, pp. 591-595
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Metabolic syndrome among patients receiving clozapine: A preliminary estimate
Grover, Sandeep; Nebhinani, Naresh; Chakrabarti, Subho; Avasthi, Ajit & Kulhara, Parmanand
Abstract
Objective : To study the prevalence of metabolic syndrome in patients receiving clozapine. Materials and Methods : For this study, 100 patients attending the psychiatry outpatient clinic of a tertiary care hospital who were receiving clozapine for more than three months were evaluated for the presence of metabolic syndrome using the International Diabetes Federation (IDF) and modified National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP-III) criteria. Results : Forty-six patients fulfilled IDF criteria and 47 met modified NCEP ATP-III criteria of metabolic syndrome. There was significant correlation between these two sets of criteria used to define the metabolic syndrome (Kappa value -0.821, P < 0.001). Among the individual parameters studied, increased waist circumference was the most common abnormality, followed by abnormal blood glucose levels and elevated triglyceride levels. All these abnormalities were seen in more than half (52-61%) of the patients. When the sample was divided into two groups, i.e., those with and without metabolic syndrome, patients with metabolic syndrome had significantly higher body mass index and had spent more time in school. Logistic regression analysis revealed that these two variables together explained about 19% of the variance in metabolic syndrome (adjusted r 2 = 0193; F = 12.8; P < 0.001). Conclusion : The findings of the present study suggest that metabolic syndrome is highly prevalent in subjects receiving clozapine.
Keywords
Clozapine, India, metabolic syndrome, prevalence
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© Copyright 2011 Indian Journal of Pharmacology. Alternative site location: http://www.ijp-online.com
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