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Antibacterial activity of the aqueous extract of Thonningia sanguinea against Extended-Spectrum-β-Lactamases (ESBL) producing Escherichia coli and Klebsiella pneumoniae strains N'guessan, J.D.; Dinzedi, M.R.; Guessennd, N.; Coulibaly, A.; Dosso, M.; Djaman, A.J. & Guede-Guina, F. Abstract Purpose: The aim of this study was to evaluate the antimicrobial activity of Thonningia sanguinea against two sensitive and two multi-drug resistant (ESBL) Enterobacteria strains namely Escherichia coli and Klebsiella pneumoniae. Method: The confirmation of the ESBL producing strains was done by the double-disc synergy tests and the broth dilution method was used for the determination of the antimicrobial parameters (MIC and MBC) on these sensitive and ESBL producing strains. Results: The two sensitive strains had the same MIC and MBC values respectively 3.125 mg /ml and 12.50 mg/ml. The ESBL producing strains also had the same MIC of 6.25 mg /ml and MBC values of 25 mg/ml. The extract was bactericidal for all tested strains. Conclusion: The results suggest that the flowers of T. sanguinea can be used in association with antibiotics for alternative therapy of diseases caused by ESBL producing E .coli, K. pneumoniae. Keywords antimicrobial activity, Thonningia sanguinea, ESBL producing strains; E .coli.

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