Purpose: To investigate the reducing effect of
Morinda citrifolia
capsules (MCC) on total cholesterol
(TC) and low-density lipoprotein cholesterol (LDL-C) in hypercholesterolemia patients.
Methods: This study was a randomized double-blind placebo-controlled clinical trial, with 60 subjects
placed in two groups, viz, experimental (MCC group) and placebo (P group). The first group received
two capsules of MCC (each capsule contains 500 mg extract) while the second group received two
capsules of placebo (comprised of 500 mg fillers) 3 times daily, for 14 days for both groups. Overnight
fasting cubiti venous blood (3 mL) was taken from each subject each time measurements were carried
out. TC and LDL-C were measured by spectrophotometric assay using an automated analyzer.
Results: The results show that there was significant decrease in TC and LDL-C on day 14, compared to
control (P group). Reduction in TC and LDL-C was 13.8 and 15.5 %, respectively. Decrease in TC and
LDL-C levels was influenced by factors, such as age, BMI, exercise, diet, and smoking habits. In MCC
group, the capsules significantly decreased TC levels (p < 0.05).
Conclusion: The results suggest that 1 g MCC, given orally thrice daily, significantly reduces TC and
LDL-C levels in patients with hypercholesterolemia.
