Purpose: To evaluate the antibiotic susceptibility pattern of various bacterial pathogens including
extended spectrum betalactamase (ESBL) producers in Kano, Nigeria.
Method: A total of 604 consecutive clinical samples obtained from Aminu Kano Teaching Hospital
(AKTH), Kano between January and July 2010 were analyzed for bacterial pathogens using standard
microbiological techniques for the isolation and identification of pathogens. Antibiotics susceptibility
tests including, ESBL screening and confirmation, were carried out by disc diffusion technique using
Clinical Laboratory Standard Institute (CLSI) criteria.
Results: Ten different types of bacteria genera were observed from nine different clinical samples.
E. coli
was the most frequently isolated bacteria (30.5 %) followed by
Staphylococcus aureus
(21.3 %).
ESBL producers showed high-level resistance against the quinolones, aminoglycoside and
cotrimoxazole but were sensitive to carbapenems and levofloxaccin. Non-ESBL organisms showed
increased resistance to amoxicillin-clavulanate, ceftazidime, cotrimoxazole, tetracycline and amoxycillin.
The prevalence of ESBL producers was 12.8 %.
E. coli,
Klebsiella pneumonia
and
Pseudomonas aeruginosa
showed ESBL production of 17.3, 14.9 and 10.0 %, respectively.
Conclusion: The findings of this study suggest that regular surveys should be carried out in this locality
to provide baseline data that would always be of clinical relevance in the treatment of patients and to
detect the emergence of multiple antibiotic resistance strains.
