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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996 EISSN: 1596-5996
Vol. 14, No. 9, 2015, pp. 1613-1619
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Bioline Code: pr15210
Full paper language: English
Document type: Research Article
Document available free of charge
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Tropical Journal of Pharmaceutical Research, Vol. 14, No. 9, 2015, pp. 1613-1619
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Impact of Co-administration of Red Palm Oil ( Elaeis guineensis Arecaceae) and Rooibos ( Aspalathus linearis Fabaceae) on Glycaemic Parameters, Liver Function and Key Glycolytic Enzymes in Diabetic Rats
Ayeleso, Ademola O.; Oguntibeju, Oluwafemi O. & Brooks, Nicole L.
Abstract
Purpose: To investigate the anti-diabetic effects of red palm oil (RPO), rooibos tea extract (RTE) and
their combination (RPO + RTE).
Methods: Diabetes was induced by a single administration of streptozotocin (50 mg/kg) and the rats
were treated for 49 days. The effects of these plant products on plasma glucose, serum insulin, serum
fructosamine, glycosylated haemoglobin (HbIAC), liver enzymes in serum and liver glycolytic enzymes
were studied using standard techniques.
Results: The combined treatment of RPO and RTE significantly (p < 0.05) decreased the glucose
(20.98 ± 6.46 mmol/L to 15.60 ± 5.94 mmol/L), HbIAC (16.74 ± 2.73 % to 12.41 ± 2.25 %), fructosamine
(98.61 ± 23.35 mmol/L to 62.52 ± 28.41 mmol/L) levels and increased insulin (0.30 ± 0.09 ng/mL to
0.72 ± 0.21 ng/mL) levels in the diabetic rats. Similarly, the combined treatment significantly (p < 0.05)
reduced alanine aminotransferase (ALT) in the serum of diabetic rats. RPO + RTE significantly (p <
0.05) increased the activity of pyruvate kinase in the liver when compared with the diabetic control
group.
Conclusion: Combined treatment with red palm oil and rooibos shows promising beneficial effects in
diabetic conditions of rats. Further studies on the mechanism of actions of the plant products are
required.
Keywords
Red palm oil; Rooibos; Glycaemic parameters; Liver function; Glycolytic enzymes; Diabetic rats
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