|
Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996 EISSN: 1596-5996
Vol. 14, No. 11, 2015, pp. 2015-2022
|
Bioline Code: pr15264
Full paper language: English
Document type: Research Article
Document available free of charge
|
|
Tropical Journal of Pharmaceutical Research, Vol. 14, No. 11, 2015, pp. 2015-2022
en |
Evaluation of Cardioprotective Effects of Genistein against Diabetes-induced Cardiac Dysfunction in Rats
Tian, Heng-Song; Zhou, Guo-Qing & Zhu, Zhi-Yong
Abstract
Purpose: To investigate the possible cardioprotective effects and potential pharmacological mechanism
of genistein.
Methods: Six-week old ZDF and lean rats were randomized into 4 groups (8 rats/group), including
group 1 (control lean rats); group 2 (lean rats treated with genistein, 2.5 mg/kg); group 3 (control ZDF
rats); and group 4 (ZDF treated with genistein). Two groups (2 and 4) were treated with genistein for 12
weeks, and cardiac functions and metabolic alterations were determined. Macrophage/monocyte
chemo-attractant protein-1 (MCP-1), vascular cellular adhesion molecule-1 (VCAM-1) and intracellular
adhesion molecule-1 (ICAM-1) secretion and their messenger RNA transcription level also were
observed.
Results: Genistein attenuated diabetes-induced cardiac dysfunction and pathological alterations, by
improving glucose tolerance and insulin resistance; facilitating Akt activation and glucose utilization, and
attenuating oxidative stress and interrelated MAP kinase and NF-κB signalling pathways. In addition,
genistein treatment markedly reduced diabetic-induced MCP-1 (83.33 %), VCAM-1 (74.66 %) and
ICAM-1 (71.42 %) secretion and mRNA transcription in ZDF rats.
Conclusion: The results demonstrate the putative effects of genistein against cardiovascular
dysfunction by improving glucose homeostasis, attenuating oxidative stress and reduced diabeticinduced
endothelial dysfunction in ZDF rats. Thus, genistein is a potential candidate for the prevention
of cardiovascular diseases.
Keywords
Cardiac dysfunction; Genistein; Oxidative stress; Inflammatory response; Insulin resistance; Glucose tolerance
|
|
© Copyright 2015 - Tropical Journal of Pharmaceutical Research Alternative site location: http://www.tjpr.org
|
|