|
Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996 EISSN: 1596-5996
Vol. 15, No. 1, 2016, pp. 149-155
|
Bioline Code: pr16021
Full paper language: English
Document type: Research Article
Document available free of charge
|
|
Tropical Journal of Pharmaceutical Research, Vol. 15, No. 1, 2016, pp. 149-155
en |
Development of Two Charge-Transfer Complex Spectrophotometric Methods for Determination of Tofisopam in Tablet Dosage Form
Alanazi, Amer; Abounassif, Mohammed; AlRabiah, Haitham & Mostafa, Gamal Abdel-Haiz
Abstract
Purpose: To develop an easy, fast and sensible spectrophotometric method for determination of
tofisopam in tablet dosage form.
Methods: Tofisopam as n-electron donor is react with two π-acceptors namely: chloranilic acid (ChA),
and 7,7,8,8 tetracyanoquinodimethane (TCNQ) to form charge-transfer complexes. The obtained
complexes were tested spectrophotometrically at 520 and 824 nm for ChA and TCNQ, respectively. The
optimal conditions affecting the reaction status were surveyed and optimized, and the results compared
with Japanese Pharmacopeia method.
Results: The calibration curve were obeyed Beer`s low in the ranges 25 – 125 and 30 – 150 μg/mL for
ChA and TCNQ, respectively. The lower limit of detection was 8.0 and 10.0 μg/m for ChA and TCNQ,
respectively. The slope and intercept of the calibration graphs were 0.0025 and 0.011, and 0.0115
and -0.237 for ChA and TCNQ, respectively
Conclusion: The proposed methods have successfully been applied to determination of tofisopam with
good accuracy and precision. The methods are accurate as the Japanese pharmacopeial method amd
may be applied for routine analysis in quality control laboratories.
Keywords
Charge-transfer complex; Tofisopam; Chloranilic acid; Tetracyanoquinodimethane; Spectrophotometry
|
|
© Copyright 2016 - Tropical Journal of Pharmaceutical Research Alternative site location: http://www.tjpr.org
|
|