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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996 EISSN: 1596-5996
Vol. 15, No. 4, 2016, pp. 885-889
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Bioline Code: pr16119
Full paper language: English
Document type: Review Article
Document available free of charge
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Tropical Journal of Pharmaceutical Research, Vol. 15, No. 4, 2016, pp. 885-889
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Autophagy in photodynamic therapy
Liang, Liming; Bi, Wenxiang & Tian, Yuanyuan
Abstract
Macroautophagy (autophagy) is crucial for cell survival during starvation and plays important roles in
human diseases. It is a highly conserved intracellular degradation system in eukaryotes for removal and
recycling of cytoplasmic components including damaged proteins and organelles to obtain energy. The
relationship between cancer and autophagy has been extensively studied in recent years. In cancer and
cancer therapy, autophagy acts as a double-edged sword. Photodynamic therapy (PDT) is a kind of
tumor therapy applied with a tumor-localizing photosensitizing agent which is followed by activation with
the light of a specific wavelength. How much is autophagy involved in photodynamic therapy? The work
in this area is still limited.
Keywords
Autophagy; Photodynamic therapy; Apoptosis; Cancer
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