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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996 EISSN: 1596-5996
Vol. 15, No. 6, 2016, pp. 1341-1348
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Bioline Code: pr16178
Full paper language: English
Document type: Review Article
Document available free of charge
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Tropical Journal of Pharmaceutical Research, Vol. 15, No. 6, 2016, pp. 1341-1348
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Natural antioxidant vitamins: A review of their beneficial roles in management of diabetes mellitus and its complications
Ayeleso, Ademola; Brooks, Nicole; Oguntibeju, Oluwafemi & Mukwevho, Emmanuel
Abstract
Diabetes mellitus is a complex and progressive metabolic disease which is associated with multiple
complications. Chronic hyperglycaemia is the defining characteristic of diabetes mellitus.
Hyperglycaemia leads to generation of free radicals and induces oxidative stress, which has become
the chief factor that leads to diabetic complications. This review supports the use of antioxidant vitamins
as therapeutic agents in the management of diabetes mellitus and its complications, and also provides
an insight into the potential pharmacological effects of natural antioxidant vitamins in diabetic conditions.
These antioxidant vitamins can be used as safe supplements to manage the occurrence and
complications of the disease. Selected studies have reported on the beneficial effects of antioxidant
vitamins in experimental models. The involvement of oxidative stress in diabetes and its complications
has made the use of natural antioxidant vitamins (free radical scavengers) from plants inevitable as they
may be very effective and safer in the management of diabetes.
Keywords
Antioxidant; Oxidative stress; Vitamins; Diabetes mellitus
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