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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996 EISSN: 1596-5996
Vol. 16, No. 2, 2017, pp. 287-296
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Bioline Code: pr17038
Full paper language: English
Document type: Research Article
Document available free of charge
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Tropical Journal of Pharmaceutical Research, Vol. 16, No. 2, 2017, pp. 287-296
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In vitro and in vivo evaluation of alginate and alginate-chitosan beads containing metformin hydrochloride
Mokhtare, Behzad; Cetin, Meltem; Ozakar, Rukiye Sevinc & Bayrakceken, Hatice
Abstract
Purpose: To prepare metformin HCl-loaded alginate (AL) and alginate-chitosan (AL-CS) beads for oral
application and to evaluate their in vitro characteristics and in vivo activities.
Methods: AL and AL-CS beads were prepared using ionotropic gelation. The beads were evaluated for
particle size, surface morphology, drug encapsulation efficiency (EE) and in vitro drug release. The anti-diabetic
effects of the beads were evaluated in diabetic Sprague Dawley rats.
Results: The mean particle sizes of AL and AL-CS beads in wet state ranged from 1714 ± 140 to 1850
± 103 μm. The EE % of AL and AL-CS beads were 33.58 ± 1.56 and 24.11 ± 1.72, respectively, with
sustained in vitro drug release of about 93 to 96 % within 8 days in phosphate buffer (PB). Optimized
metformin HCl-loaded AL and AL-CS beads showed significant hypoglycaemic effects in diabetic rats
over a prolonged period (about 12 h) after oral administration compared to the pure drug (p < 0.05).
Conclusion: Metformin HCl-loaded AL and AL-CS beads for oral application may be useful in
prolonging the hypoglycaemic effect of metformin. This is capable of increasing patients’ compliance to
the medication.
Keywords
Alginate; Beads; Chitosan; Metformin; Diabetes; In vivo study
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