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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996 EISSN: 1596-5996
Vol. 16, No. 5, 2017, pp. 981-988
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Bioline Code: pr17126
Full paper language: English
Document type: Research Article
Document available free of charge
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Tropical Journal of Pharmaceutical Research, Vol. 16, No. 5, 2017, pp. 981-988
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Dissolution and permeation characteristics of artemether tablets formulated with two gums of different surface activity
Olorunsola, Emmanuel O; Bhatia, Partap G; Tytler, Babajide A; Adedokun, Musiliu O & Adikwu, Michael U
Abstract
Purpose: To evaluate the dissolution and permeation characteristics of artemether tablets formulated
with cashew and prosopis gums, and compare with tablets prepared with acacia gum.
Methods: Artemether tablets containing varying concentrations (1.0 to 4.0 %w/w) of cashew and
prosopis gums or 3 %w/w of acacia (control) gum as binders were formulated by wet granulation
method. The tablets were evaluated for crushing strength, friability and disintegration time. Dissolution
and permeation characteristics of the formulations were studied using USP methods.
Results: Tablets formulated with prosopis gum had higher crushing strength, higher friability and higher
disintegration time compared to those of cashew gum at corresponding binder concentrations. Tablets
formulated with 3 %w/w cashew gum exhibited complete drug release within 1 h, 95 % drug permeation
in 188 min (in simulated gastric fluid [SGF]) and 95 % permeation in 224 min (under simulated intestinal
fluid [SIF] condition) while those made with 3 %w/w prosopis gum exhibited 70.7 % drug release in 1 h,
95 % permeation in 135 min (in SGF) and 95 % permeation in 170 min (under SIF condition).
Conclusion: Cashew gum is effective as a binder over a relatively wide range of concentrations to
achieve fast drug release though with minimal permeation enhancement while prosopis gum is
characterized by delayed drug release but enhanced permeation of the released drug.
Keywords
Cashew gum; Acacia; Prosopis; Artemether; Drug release; Dissolution; Permeation
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