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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996 EISSN: 1596-5996
Vol. 16, No. 5, 2017, pp. 989-996
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Bioline Code: pr17127
Full paper language: English
Document type: Research Article
Document available free of charge
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Tropical Journal of Pharmaceutical Research, Vol. 16, No. 5, 2017, pp. 989-996
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Antihyperglycaemic and hypolipidemic effect of methanol extracts of Ageratum conyzoides L (Asteraceae) in normal and diabetic rats
Atawodi, Sunday E; Adepoju, Oluwafemi A & Nzelibe, Humphrey C
Abstract
Purpose: To investigate the antihyperglycaemic and hypolipidemic potential of the methanol extracts of
leaf, stem and root of Ageratum conyzoides in streptozotocin (STZ)-induced diabetic rats.
Methods: The extract of each of the plant part was obtained by extraction in methanol. A total of 60
male Wistar albino rats (30 induced with diabetes and 30 normoglycaemic) were assigned into diabetic
and normoglycaemic groups of 6 rats each. Methanol extracts of leaf, stem and root of Ageratum
conyzoides were administered orally at a dose of 100 mg/kg to the rats for a period of 14 days, with
glibenclamide as the standard drug (1 mg/kg). Fasting blood glucose and lipid profile were determined
to ascertain the antihyperglycaemic and hypolipidemic activities of the different parts of the plant.
Results: Ageratum conyzoides significantly (p < 0.05) reduced fasting blood glucose (FBG) levels in
diabetic rats by 38.71 ± 19.41 % (leaf), 25.64 ± 20.53 % (stem), and 34.76 ± 18.03 % (root) on day 14 of
the treatment, compared with untreated diabetic rats where FBG increased by 11.33±8.91 %. Total
cholesterol (leaf, 119.10 ± 8.12 mg/dl; stem, 109.28 ± 8.13 mg/dl) and triglycerides (leaf, 61.71 ± 9.37
mg/dl; stem, 72.45 ± 3.39 mg/dl) levels were also significantly (p < 0.05) lowered in diabetic rats. Low
density lipoprotein cholesterol (leaf, 77.21 ± 8.12 mg/dl; stem, 64.76 ± 8.04 mg/dl; root, 79.08 ± 10.61
mg/dl) levels were significantly (p < 0.05) lowered in all treated diabetic groups compared with the
untreated diabetic rats (103.19 ± 6.08 mg/dl).
Conclusion: The results from this study indicate that Ageratum conyzoides has hypoglycaemic and
hypolipidemic properties in rats, and this probably justifies its reported use in the traditional
management of diabetes mellitus.
Keywords
Ageratum conyzoides; Diabetes mellitus; Antihyperglycaemic; Hypolipidemic
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