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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996 EISSN: 1596-5996
Vol. 16, No. 7, 2017, pp. 1545-1552
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Bioline Code: pr17197
Full paper language: English
Document type: Research Article
Document available free of charge
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Tropical Journal of Pharmaceutical Research, Vol. 16, No. 7, 2017, pp. 1545-1552
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Antioxidant effect of Arabian coffee ( Coffea arabica L) blended with cloves or cardamom in high-fat diet-fed C57BL/6J mice
Alshammari, Ghedeir M; Balakrishnan, Aristatile & Khalifa, Abdulrahman Al-
Abstract
Purpose: To investigate the antioxidant activity of Coffea Arabica L in high-fat diet (HFD)-fed C57BL/6J
mice.
Methods: A decoction of Arabian coffee blended with or without cardamom or cloves was orally
administered to HFD-fed C57BL/6J mice for a period of 60 days. At the end of the treatment, blood and
tissue samples were taken to evaluate various parameters, including lipid peroxidation markers and
antioxidants such as paraoxonase (PON1), superoxide dismutase (SOD), glutathione peroxidase (GPx),
vitamin C, vitamin E, reduced glutathione (GSH) and catalase (CAT).
Results: The activities of antioxidant enzymes (PON1, SOD, CAT, and GPx) and non-enzymatic
antioxidants (GSH, vitamins C and E) were significantly elevated (p < 0.05) in mice administered
Arabian coffee plus cardamom compared with those administered HFD alone or coffee alone. The
levels of thiobarbituric reactive substances and oxidized LDL antibody (oxLDL-Ab) decreased
significantly (p < 0.05) in mice administered Arabian coffee plus cardamom compared with those
administered Arabian coffee plus cloves.
Conclusion: The results indicate that Arabian coffee blended with cardamom or cloves exhibited
enhanced free radical scavenging and antioxidant properties compared with those that received Arabic
coffee alone. However, coffee with cardamom had more pronounced effects than coffee with cloves.
Keywords
High-fat diet; Diabetes; Antioxidant; Arabian coffee; Cardamom; Cloves
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