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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996 EISSN: 1596-5996
Vol. 16, No. 7, 2017, pp. 1573-1578
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Bioline Code: pr17200
Full paper language: English
Document type: Research Article
Document available free of charge
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Tropical Journal of Pharmaceutical Research, Vol. 16, No. 7, 2017, pp. 1573-1578
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Anti-diabetic potential of aerial parts of Galium tricornutum (Dandy) Rubiaceae
Khan, Shah Tamas; Ahmed, Mushtaq; Khan, Rahmat Ali; Mushtaq, Nadia & Khan, Nisar
Abstract
Purpose: To evaluate the anti-diabetic potential of methanol extract of the aerial parts of Galium
tricornutum (Dandy) in diabetic rats.
Methods: The methanol extract of the aerial parts of Galium tricornutum was first subjected to acute
toxicity studies. Thereafter, the effect of the extract on oral glucose tolerance was determined. In
addition, the effect of the extract on fasting blood glucose, as well as serum lipid profile, urea,
creatinine, alanine transaminase (ALT), aspartate transaminase (AST), bilirubin, alkaline phosphatase
(ALP) and protein were investigated in alloxan-induced diabetic rats.
Results: No acute toxicity were observed in the rats after administration of the plant extract up to a
dose of 2000 mg/kg. The effect of the extract on glucose tolerance test was significant from 30 to 180
min after treatment. In the diabetic rats, the extract showed significant (p < 0.05) anti-hyperglycemic
activity at 400 mg/kg. It also led to significant increases in body weight and HDL-cholesterol, and
significant reductions in serum LDL, triglycerides and transaminases (p < 0.05).
Conclusion: These results indicate that the aerial parts of G. tricornutum possess significant antidiabetic
potential.
Keywords
Diabetes; Galium tricornutum; Glibenclamide; Glucose tolerance tes; Lipid profile
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