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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996 EISSN: 1596-5996
Vol. 16, No. 7, 2017, pp. 1621-1629
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Bioline Code: pr17207
Full paper language: English
Document type: Research Article
Document available free of charge
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Tropical Journal of Pharmaceutical Research, Vol. 16, No. 7, 2017, pp. 1621-1629
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Relationship between single-nucleotide polymorphisms in un-translated region of human leukocyte antigen-G and preeclampsia
Zhang, Zhan; Zhang, Nan; Zhang, Linlin; Jia, Liting & Li, Hong
Abstract
Purpose: The aim of this study was to unravel the link between human leukocyte antigen-G untranslated
region (HLA-G 3-UTR) single-nucleotide polymorphism (SNP) and preeclampsia by
examining polymorphisms in HLA-G 3-UTR in preeclampsia patients and their newborns, as well as
those of women with normal pregnancy and their newborns.
Methods: Single pregnant mothers and their newborns at the Third Affiliated Hospital of Zhengzhou
University, China, were divided into preeclampsia group (144 cases), and normal pregnancy group (122
cases). Blood samples from the two groups were collected for DNA extraction, and the DNA samples
were analyzed for HLA-G 3'-UTR SNP by polymerase chain reaction (RT-PCR) and direct sequencing
method.
Results: The frequency of CG genotype in HLA-G 3-UTR 3127 gene in the preeclampsia group was
significantly lower, while the frequency of AA genotype in HLA-G 3-UTR 3172 gene in the preeclampsia
group was significantly higher (p < 0.05) when compared with the normal pregnancy group.
Furthermore, frequencies of the compatible genotype AA/AA (mothers/newborns) in HLA-G 3-UTR 3172
gene in the preeclampsia group were significantly higher relative to the normal pregnancy group (p<
0.05).
Conclusion: These results suggest that when CC/GG is the compatible genotype in HLA-G 3-UTR
3127 gene of mothers/newborns, preeclampsia risk may decrease, but it may increase if the compatible
genotype is AA/AA. Thus, SNP in HLA-G 3-UTR 3127 gene may be a protective factor against
preeclampsia in Chinese Han pregnant women, while SNP in 3172 gene may be associated with
susceptibility to preeclampsia.
Keywords
Single-nucleotide polymorphisms; Human leukocyte antigen-G; Un-translated Region; Preeclampsia
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