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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996 EISSN: 1596-5996
Vol. 16, No. 7, 2017, pp. 1703-1709
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Bioline Code: pr17216
Full paper language: English
Document type: Research Article
Document available free of charge
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Tropical Journal of Pharmaceutical Research, Vol. 16, No. 7, 2017, pp. 1703-1709
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A study on the interaction between metformin and constituents of a commercial herbal product
Arhewoh, Matthew I; Eraga, Sylvester O; Irabor, Jonah & Iwuagwu, Magnus A
Abstract
Purpose: To investigate the interactions between metformin and Yoyo Bitters® including some of its
constituents in the management of diabetes mellitus.
Method: Using the generic form of metformin (Glucophage®) tablets, tests such as disintegration time,
dissolution profile, Fourier transform infrared (FTIR) spectroscopy and in vivo hypoglycaemia tests using
Wistar albino rat were performed for metformin to investigate its behaviour in the presence and absence
of Yoyo Bitters and some plant extracts used in its formulation.
Results: Metformin tablets used met BP specification in terms of pharmaceutical properties. There was
no significant change in the disintegration properties of the metformin tablets in the presence of Yoyo
Bitters (p > 0.05) while a significant change occurred in the dissolution profile (p < 0.05). The FTIR
spectra showed some level of interactions due to disappearance of some spectral peaks. In vivo result showed a significant reduction (p < 0.05) in the duration of action of metformin.
Conclusion: Concomitant administration of metformin and Yoyo Bitters showed interaction that
appeared antagonistic to the hypoglycaemic effect of metformin both in vitro and in rat models
Keywords
Metformin; In vitro interactions; Yoyo Bitters; Diabetes
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