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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996 EISSN: 1596-5996
Vol. 16, No. 7, 2017, pp. 1737-1746
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Bioline Code: pr17219
Full paper language: English
Document type: Review Article
Document available free of charge
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Tropical Journal of Pharmaceutical Research, Vol. 16, No. 7, 2017, pp. 1737-1746
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Quality of life of healthy subjects and patients with arthritis and diabetes mellitus in Bayelsa State, Niger Delta region
Omodanisi, Elizabeth I; Aboua, Guillaume Y & Oguntibeju, Oluwafemi O
Abstract
Purpose: There is paucity of information about quality of life (QOL) studies among patients with arthritis
and diabetes mellitus in developing countries. The objective of this study was to evaluate quality of life
of patients with arthritis (AR) and diabetes mellitus (DM).
Methods: A total of 507 subjects comprising 364 healthy adult volunteers and 143 hospitals patients
with arthritis and diabetes mellitus were enrolled into the study. Data were collected using Ferrans and
Powers QOL index (QLI). The generic version and disease specific versions were administered to
healthy subjects and hospital patients respectively and the data analyzed.
Results: The highest mean overall QOL scores of the healthy subjects (364; 71.79%) which ranged
from 24.43(SD=4.08) to 26.62 (SD=2.15) (95% CI 24.94-27.27) is the second most desirable category
of QOL rating relative to the reference standard score of zero to 30 for the worst and best case
scenarios respectively. This was distantly followed by patients with diabetes mellitus alone (slightly
satisfied) with mean OQOL score of 18.92 (SD=2.59; 95% CI 16.03-19.24). Subjects with AR had lower
OQOL than diabetic subjects with mean OQOL scores of 15.98 (SD=2.75; 95% CI 13.15-16.77). The
least mean OQOL score (moderately dissatisfied) was recorded for patients with AR co-existing with
other chronic illnesses with a mean OQOL scores of 8.92 (SD=3.97; 95%CI 7.36 - 13.4). There was
statistically significant difference between the OQOL of healthy subjects and patients with arthritis and
diabetes mellitus (p<0.0001). A strong association also exists between OQOL and age, marital status,
employment and gender (p<0.05).
Conclusions: Arthritis and diabetes mellitus severely impaired patient QOL. Arthritis has more
pronounced effects on QOL either alone or as co-morbid chronic illness. Concerted efforts at stemming
the prevalence of these conditions, supportive roles for the elderly and married women as well as cost
effective management of these conditions among others must be put in place.
Keywords
Moringa oleifera; Diabetes mellitus; Hyperglycemia; Oxidative stress.
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