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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996 EISSN: 1596-5996
Vol. 16, No. 8, 2017, pp. 1983-1988
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Bioline Code: pr17251
Full paper language: English
Document type: Research Article
Document available free of charge
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Tropical Journal of Pharmaceutical Research, Vol. 16, No. 8, 2017, pp. 1983-1988
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A curve model for association of serum homocysteine with carotid artery hemodynamics
Wu, Zewei; Wen, Yufeng; Liu, Mengxue; Li, Haibo; Zhu, Yu; Zhang, Huiping & Ren, Tiantian
Abstract
Purpose: To investigate the correlation between carotid artery hemodynamics and serum
homocysteine.
Methods: A total of 894 participants made up of 439 male (49.11 %) and 455 female (50.89 %) from
Ma’anshan, China, enrolled in the cross-sectional study. Data collection included demographics, blood
sample and carotid ultrasonography. Piecewise linear regression analysis was used to analyze the
relationship between serum homocysteine and carotid artery hemodynamics.
Results: Homocysteine (Hcy) levels were divided into four groups by quartiles. The populations of the
groups were 226, 220, 222, 226; and their mean ages were 56.52 ± 10.49, 62.27 ± 10.06, 63.42 ± 9.81
and 65.38 ± 10.56 years, respectively. After adjustment for blood biochemical and demographics
factors, U-shaped and S-shaped curves were as observed between Hcy and carotid artery
hemodynamics. The adjusted regression analysis showed that the threshold values of Hcy with end
diastolic velocity (EDV) of right common carotid artery (CCA) were 12.50 and 19.00, while for the EDV
of right internal carotid artery (ICA), the values were 11.50 and 22.00. U-shaped curves were observed
between Hcy and peak systolic velocity (PSV) of left CCA, EDV of left CCA, PSV of left ICA and EDV of
left ICA. The threshold values of Hcy with PSV of left CCA, EDV of left CCA, PSV of left ICA and EDV of
left ICA were 14.00, 14.00, 14.00 and 13.50, respectively.
Conclusion: These results indicate that a significant correlation exists between homocysteine at
different concentrations and carotid artery hemodynamics.
Keywords
Homocysteine; Hemodynamics; End diastolic velocity; Peak systolic velocity
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