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Iranian Journal of Pharmacology and Therapeutics
Razi Institute for Drug Research (RIDR) of Iran University of Medical Sciences and Health Services (IUMS)
ISSN: 1735-2657
Vol. 1, No. 1, 2002, pp. 5-7
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Bioline Code: pt02002
Full paper language: English
Document type: Research Article
Document available free of charge
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Iranian Journal of Pharmacology and Therapeutics, Vol. 1, No. 1, 2002, pp. 5-7
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Diazoxide, a KATP Channel Opener, Prevented Ethanol-Induced Gastric Ulceration in Rats
Majid Rahgozar, Hamid Reza Pazoki Toroudi, azam Bakhtiarian, and Bijan Djahanguiri
Abstract
Ethanol-induced acute gastric ulceration (EIGU) is widely studied. ATP dependent potassium channel (KATP) modulators are thought to interfere with some physiologic functions of the stomach. We have studied the effects of different doses of KATP modulators (diazoxide as agonist and glibenclamide as antagonist) on EIGU in rats. Gastric lesions were quantified. Fasting blood glucose (FBS) levels were measured enzymatically. EIGU was prevented by diazoxide and aggravated by glibenclamide. Diazoxide increased and glibenclamide decreased FBS respectively. The present study shows that KATP modulators are involved in the production of EIGU with a mechanism which remains to be elucidated.
Keywords
ethanol, potassium channel modulators, rats, stomach ulceration
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© Copyright 2002 - Razi Institute for Drug Research (RIDR)
Alternative site location: http://ijpt.iums.ac.ir/
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