Ethanol (90%) extract of
Ammania baccifera
(L.) whole plant (EEAB) was evaluated for possible antisteroidogenic activity in mature female mice ovaries. The ethanol extract at the doses of 100, 200 and 400 mg /kg body weight (i.p) arrested the normal estrus cycle at dioestrus phase and significantly decreased weight of ovaries. The cholesterol and ascorbic acid content in ovaries were significantly elevated in treated mice. The extract also significantly inhibited the activity ofΔ
5-3β-hydroxy steroid dehydrogenase (Δ
5-3β-HSD) and Glucose-6-phosphate dehydrogenase (G-6-PD), the two key enzymes involved in ovarian steroidogenesis. Results of this study suggested that the ethanol extract of whole plant of
Ammania baccifera (L.) acts as an antisteroidogenic agent.
