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International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433 EISSN: 1680-6433
Vol. 15, No. 3, 2017, pp. 155-160
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Bioline Code: rm17021
Full paper language: English
Document type: Research Article
Document available free of charge
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International Journal of Reproductive BioMedicine, Vol. 15, No. 3, 2017, pp. 155-160
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Serum ferritin concentration in early pregnancy and risk of subsequent development of gestational diabetes: A prospective study
Soheilykhah, Sedigheh; Mojibian, Mahdieh & Moghadam, Maryam Jannati
Abstract
Background: Elevated serum ferritin concentration is associated with insulin
resistance and diabetes. Recently it has also been described in gestational diabetes
mellitus (GDM).
Objective: A prospective study was done to determine whether there was a
relationship between serum ferritin concentration in early pregnancy and the risk of
GDM.
Materials and Methods: A study was performed on 1,384 pregnant women with
gestational age of 12-16 weeks. A blood sample was obtained for measurement of
ferritin in the first trimester. Diagnosis of GDM was done by 75 gr oral glucose
tolerance test between 24-28 wk.
Results: Women who developed GDM had a higher concentration of serum ferritin
than women who did not develop GDM (p=0.01). A ferritin concentration of 45
ng/ml was calculated to be the 75th percentile for healthy pregnant women.
Considering this level 32% in the GDM group and 25.2% of normal subjects
exhibited high ferritin levels (p=0.01). The risk of GDM with these high levels of
ferritin was 1.4-fold higher than that for subjects with lower concentrations. The
Odds Ratio was 1.4 (95% CI= 1-1.87) (p=0.01). After adjusted for age Odds Ratio
was 1.38 (95% CI=1.02-1.86) (p=0.03) and after adjustment for pre-pregnancy Body
Mass index, the adjusted odds ratio was 1.31 (CI= 0.96-1.79) (p=0.08). After
multivariable adjustment (age and body mass index), the adjusted odds ratio was 1.3
(0.95-1.8) (p=0.09).
Conclusion: High serum ferritin can be regarded as a significant risk factor for the
development of gestational diabetes.
Keywords
Ferritin; Gestational Diabetes
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