|
International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433 EISSN: 1680-6433
Vol. 15, No. 7, 2017, pp. 435-440
|
Bioline Code: rm17055
Full paper language: English
Document type: Research Article
Document available free of charge
|
|
International Journal of Reproductive BioMedicine, Vol. 15, No. 7, 2017, pp. 435-440
en |
Controlled ovarian stimulation with r-FSH plus r-LH vs. HMG plus r-FSH in patients candidate for IVF/ICSI cycles: An RCT
Tehraninejad, Ensieh Shahrokh; Taghinejad, Mina Farshbaf; Rashidi, Batool Hossein & Haghollahi, Fedyeh
Abstract
Background: Different combination of gonadotropin preparation has been
introduced with no definite superiority of one over others in in vitro fertilization
(IVF), but individualized regimens for each patient are needed.
Objective: The aim of the present study was to investigate the effect of controlled
ovarian stimulation with recombinant- follicle stimulating hormone (r-FSH) plus
recombinant-luteinizing hormone (rLH) versus human menopausal gonadotropin
(HMG) plus r-FSH on fertility outcomes in IVF patients.
Materials and Methods: This is a randomized clinical trial study that was
performed from October 2014-April 2016 on 140 infertile patients with a set of
inclusion criteria that referred to infertility clinics in Vali- asr and Gandhi Hospital
in Tehran. The women were randomly divided into two treatment groups. The first
group (n=70) received rFSH from the second day of cycle and was added HMG in
6th day and the 2nd group (n=70), received rFSH from the second day of cycle and
was added recombinant-LH in 6th day. Then ovum Pick-Up and embryo transfer
were performed. In this study, we assessed the outcomes such as; chemical and
clinical pregnancy rate, live birth and abortion rate.
Results: Number of follicles in ovaries, total number of oocytes or M2 oocytes and
quality of fetuses has no significant differences between two groups (p>0.05). Total
number of fetuses were significantly higher in patients who received rFSH + HMG
(p=0.02). Fertility outcomes consisted of: live birth rate, chemical pregnancy and
clinical pregnancy rate were higher in rFSH + HMG group in comparison to rFSH
+r-LH group (p<0.05).
Conclusion: It seems that in IVF patients, HMG + rFSH used for controlled ovarian
hyperstimulation have better effects on fertility outcomes, but in order to verify the
results, it is recommended to implement studies on more patients.
Keywords
Ovulation induction; Recombinant-FSH; Recombinant-LH; Human menopausal gonadotropin; IVF; ICSI
|
|
© Copyright [2017] - International Journal of Reproductive BioMedicine Alternative site location: http://www.ijrm.ir
|
|