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Basic and clinical genetic studies on male infertility in Iran during 2000-2016: A review
Moghbelinejad, Sahar; Mozdarani, Hossein; Ghoraeian, Pegah & Asadi, Reihaneh
Abstract
The male factor contributes to 50% of infertility. The cause of male infertility is
idiopathic and could be congenital or acquired. Among different factors which are
involved in idiopathic male infertility, genetic factors are the most prevalent causes
of the disease. Considering, the high prevalence of male infertility in Iran and the
importance of genetic factors in the accession of it, in this article we reviewed the
various studies which have been published during the last 17 yr on the genetic basis
of male infertility in Iran. To do this, the PubMed and Scientific information
database (SID) were regarded for the most relevant papers published in the last 17 yr
referring to the genetics of male factor infertility using the keywords “genetics”,
“cytogenetic”, “male infertility”, and “Iranian population”. Literatures showed that
among the Iranian infertile men Yq microdeletion and chromosomal aberrations are
two main factors that intervene in the genetics of male infertility. Also, protamine
deficiency (especially P2) is shown to have an influence on fertilization rate and
pregnancy outcomes. The highest rate of sperm DNA damages has been found
among the asthenospermia patients. In several papers, the relation between other
important factors such as single gene mutations and polymorphisms with male
infertility has also been reported. Recognition of the genetic factors that influence
the fertility of Iranian men will shed light on the creation of guidelines for the
diagnosis, consultation, and treatment of the patients."
Keywords
Iran; Male infertility; Genetics; Cytogenetic; Peripheral blood; Sperm.
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