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International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433 EISSN: 1680-6433
Vol. 17, No. 10, 2019, pp. 709-716
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Bioline Code: rm19074
Full paper language: English
Document type: Research Article
Document available free of charge
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International Journal of Reproductive BioMedicine, Vol. 17, No. 10, 2019, pp. 709-716
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Artificial colloids versus human albumin for the treatment of ovarian hyperstimulation syndrome: A retrospective cohort study
Minami, Tetsuji; Yamana, Hayato; Shigemi, Daisuke; Matsui, Hiroki; Fushimi, Kiyohide & Yasunaga, Hideo
Abstract
Background: The optimal colloid solution for the treatment of ovarian hyperstimulation syndrome (OHSS) remains to be established.
Objective: We aimed to compare artificial colloids (AC) with human albumin (HA) for the treatment of OHSS.
Materials and Methods: In this retrospective cohort study, data for OHSS participants were collected from a national inpatient database in Japan. The participants received intravenous fluid management with AC (n=156) or HA (n=127). We compared the two groups in terms of the length of stay, development of post-treatment complications, and termination surgery.
Results: In multivariable linear regression analyses for log-transformed length of stay with reference to the OHSS participants receiving AC, the regression coefficient (95% confidence interval) in participants receiving HA was 0.03 (-0.04-0.09, p = 0.42). Thromboembolism occurred in two participants in the HA group and three participants in the AC group. Two participants in the HA group suffered renal failure during hospitalization. No participants underwent termination surgery in the two groups.
Conclusions: The present results showed comparable efficacy between AC and HA for the treatment of OHSS. There were no significant differences in post-treatment complications between the two groups.
Keywords
Ovarian hyperstimulation syndrome; Treatment; Colloid; Length of stay.
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© Copyright 2019 - Tetsuji Minami et al. Alternative site location: http://www.ijrm.ir
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