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The relationship of hyperlipidemia with maternal and neonatal outcomes in pregnancy: A cross-sectional study
Sharami, Seyedeh Hajar; Ranjbar, Zahra Abbasi; Alizadeh, Fatemeh & Kazemnejad, Ehsan
Abstract
Background: Concentrations of plasma lipids levels during pregnancy clearly
increases. According to some studies, dyslipidemia is effective in the incidence of
preeclampsia and insulin resistance.
Objective: This study aimed to examine the relationship between hyperlipidemia and
maternal and neonatal outcomes in pregnant women.
Materials and Methods: This is a cross-sectional study which was conducted on two
groups of pregnant women with hyperlipidemia and normal ones to assess maternal
and neonatal outcomes. Maternal data including gestational age, mother’s age, body
mass index, and maternal weight gain during pregnancy, gestational diabetes mellitus,
preeclampsia, cholestasis, and delivery method. Also, birth weight and Apgar score
were gathered as the neonatal outcomes.
Results: The results showed that the prevalence of abnormal lipid parameters
increased with increasing gestational age. In pregnant women with dyslipidemia in
combination with increased triglyceride, cholesterol and Low-density lipoprotein, and
decreased High-density lipoprotein, the incidence rates of gestational diabetes (p <
0.001), preeclampsia (p < 0.001), cholestasis (p = 0.041), fetal growth retardation (p <
0.001), and macrosomia (p < 0.001) were statistically higher.
Conclusion: Dyslipidemia was associated with some adverse effects of pregnancy
and harmful fetal outcomes. Therefore, it seems that adding laboratory assessment
of lipid profiles before and during pregnancy can be effective in early diagnosis of
dyslipidemia.
Keywords
Dyslipidemias; Gestational diabetes; Preeclampsia; Fetal macrosomia.
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