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International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433 EISSN: 1680-6433
Vol. 17, No. 10, 2019, pp. 749-756
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Bioline Code: rm19078
Full paper language: English
Document type: Research Article
Document available free of charge
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International Journal of Reproductive BioMedicine, Vol. 17, No. 10, 2019, pp. 749-756
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The effect of Myo-inositol on sperm parameters and pregnancy rate in oligoasthenospermic men treated with IUI: A randomized clinical trial
Ghasemi, Afsane; Amjadi, Fatemehsadat; Mirsaeed, Seyedeh Masoumeh Ghazi; Beigi, Robabeh Mohammad; Ghasemi, Samaneh; Moradi, Yousef & Mirsaeed, Seyedeh Tahereh Ghazi
Abstract
Background: In about 40% of the couples, the cause of infertility problems is attributed
to men because of low sperm production and disturbed motility of sperm. Pieces
of evidence show that Myo-inositol has a potential role for the treatment of sperm
morphology and male fertility.
Objective: This study aimed to determine the effect of Myo-inositol on the sperm
parameters and fertility rate in patients with oligoasthenospermia treated by intrauterine
insemination (IUI).
Materials and Methods: This study was a randomized clinical trial conducted on 37
patients with oligoasthenospermia treated by IUI during 2016-2017. In this study, the
patients were randomly divided into two groups of oligoasthenospermia treated with
(Case group) and without Myo-inositol (Control group). The case group received 0.5 ml
of Myo-inositol with a concentration of 2 mg/ml and incubated at 37°C incubator for 2
hr, but the control group had no interventions.
Results: The results of this study showed that although there was no significant
difference in sperm parameters including sperm motility and concentration before
processing with Myo-inositol in the case group, but there was a significant increase
in sperm motility during the treatment with Myo-inositol. The therapeutic effect of this
method was confirmed on induction of pregnancy in 18% of the treated patients, in
such a way that was about twice greater than those who did not receive the drug.
Conclusion: According to the results of this study, the use of Myo-inositol is efficient
enough to change sperm parameters to increase the chance of fertility.
Keywords
Myo-inositol; Pregnancy; Sperm; Motility; Oligoasthenospermic.
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© Copyright 2019 - Afsane Ghasemi et al. Alternative site location: http://www.ijrm.ir
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