![](/imgs/covers/rm_cover.jpg)
|
International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433 EISSN: 1680-6433
Vol. 18, No. 1, 2020, pp. 11-20
|
Bioline Code: rm20002
Full paper language: English
Document type: Research Article
Document available free of charge
|
|
International Journal of Reproductive BioMedicine, Vol. 18, No. 1, 2020, pp. 11-20
en |
The comparison of plasma fibronectin in term and preterm delivery: A cross-sectional, descriptive-analytical study
Moradi, Zahra; Moradi, Parvin; Meshkibaf, Mohamad Hassan; Aleosfoor, Mehrnoosh; Sharafi, Mehdi & Jafarzadeh, Saeedeh
Abstract
Background: Preterm delivery is one of the main causes of infant death. Therefore,
prediction of preterm delivery may eliminate a large number of prenatal complications.
Objective: The present study aimed to understand if preterm delivery can be predicted
by assessing maternal plasma fibronectin concentration.
Materials and Methods: Serum samples from 105 pregnant women participating in this
study were collected. The plasma fibronectin were measured at 24-28 wk of gestation
and again at 32-36 wk of gestation. Unfortunately, only 65 of the 105 pregnant women,
returned for the second sampling. The plasma fibronectin was analyzed using ELISA
method and its concentration in term and preterm deliveries was compared. The
delivery dates of all the women were also recorded.
Results: Out of 105 pregnant women, 28 delivered preterm (26.7%). The Plasma
fibronectin concentrations in women with preterm delivery were higher than in those
who delivered at term (p = 0.001). Accordingly, Plasma fibronectin concentrations
were significantly higher in the second serum samples (p = 0.01). Plasma fibronectin
concentrations was also higher in obese women and in those suffering from
preeclampsia (p = 0.12) and gestational diabetes (p = 0.81).
Conclusion: Plasma fibronectin concentrations test could be used as an optional
screening test for preterm delivery at 28 to 34 wk of gestation in pregnant women
who prefer to avoid vaginal sampling.
Keywords
Premature birth; Fibronectin; Maternal serum screening tests.
|
|
© Copyright 2020 - Moradi et al. Alternative site location: http://www.ijrm.ir
|
|