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Effects of selenium supplementation on glucose homeostasis in women with gestational diabetes mellitus: A randomized, controlled trial
Najib, Fatemeh Sadat; Poordast, Tahereh; Nia, Mina Rezvan & Dabbaghmanesh, Mohammad Hossein
Abstract
Background: There is limited evidence about the anti-diabetic effects of selenium
supplementation in women with gestational diabetes mellitus (GDM).
Objective: This study investigates the effects of selenium supplementation on glucose
homeostasis in women with GDM.
Materials and Methods: A total of 60 pregnant women with GDM were enrolled in this
prospective randomized, double-blind, and placebo-controlled clinical trial. They were
randomly assigned to take either 100μg selenium supplements as tablet or a placebo
daily for 12 wk since 24-28 wk of gestation. The primary outcomes were changes in the
glucose homeostasis, including fasting plasma glucose, the 2-hr post prandial blood
glucose, serum insulin level, glycosylated hemoglobin (Hb A1C), and the homeostasis
model assessment of insulin resistance(HOMA_IR) at the initial period and 3 months
after intervention.
Results: The mean maternal age of the patients who took selenium supplements was
29.19 ± 6.16 (range 18-41) years. In the placebo group, the mean maternal age was 31 ±
4.43 (range 24-39) years. Compared with the placebo group, fasting plasma glucose, 2-hr post-prandial blood glucose, glycosylated hemoglobin(Hb A1C), serum insulin level,
and homeostasis model of assessment-estimated insulin resistance(HOMA_IR) were
not significantly changed in the selenium group at the end of study (p = 0.25, p = 0.87,
p = 0.34, p = 0.57, and p = 0.31, respectively).
Conclusion: The results of this trial suggest that supplementation with 100μg of
selenium does not modulate glucose homeostasis in women with GDM.
Keywords
Diabetes; Gestational; Selenium.
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