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International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433 EISSN: 1680-6433
Vol. 18, No. 6, 2020, pp. 465-470
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Bioline Code: rm20050
Full paper language: English
Document type: Research Article
Document available free of charge
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International Journal of Reproductive BioMedicine, Vol. 18, No. 6, 2020, pp. 465-470
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Dual stimulation in unexpected poor responder POSEIDON classification group 1, sub–group 2a: A cross-sectional study
Eftekhar, Maryam; Mohammadi, Banafsheh; Khani, Parisa & Mortazavi Lahijani, Maryam
Abstract
Background: Poor ovarian response management is a complex and controversial issue
in the field of reproductive medicine.
Objective: The aim of this study was to apply double stimulation in the same cycle
in unexpected poor responders in POSEIDON classification group 1, sub group 2a
and compare assisted reproductive technology outcomes between luteal phase and
follicular phase ovarian stimulation.
Materials and Methods: In this cross-sectional study, 10 women with age < 35 yr,
antral follicle count > 5, and anti-müllerian hormone > 1.2 ng/mL were enrolled. All
participants received conventional antagonist protocol in the follicular phase and only
the cycles with retrieved oocytes < 4 in this phase included. The luteal phase ovarian
stimulation was initiated from the day of first oocytes retrieval by 300 IU of human
menopausal gonadotropin / day. When dominant follicles amounted to 14 mm in mean
diameter, 0.25 mg/day of gonadotropin-releasing hormone antagonist was initiated
and 10,000 IU human chorionic gonadotropin was injected when at least two follicles
with a mean diameter of 17 mm were observed. Oocyte retrieval was carried out 34-36
hr following human chorionic gonadotropin injection. Finally, a comparison was made
between the two phase in terms of the number of retrieved oocytes as well as the
number of obtained embryos and fertilization rates.
Results: Numbers of retrieved oocytes (p = 0.004), mature oocytes (p = 0.016), and
embryos (p = 0.013) was significantly higher in luteal phase in compared with follicular
phase. Quality of embryos was similar in two phases.
Conclusion: Double stimulation protocol can increase number of retrieved oocytes in
unexpected PORs.
Keywords
Dual stimulation; Poor responder; POSEIDON classification; Luteal-phase; Follicular phase; Ovarian stimulation.
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© Copyright [2020] - Eftekhar et al. Alternative site location: http://www.ijrm.ir
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