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International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433 EISSN: 1680-6433
Vol. 18, No. 7, 2020, pp. 531-538
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Bioline Code: rm20057
Full paper language: English
Document type: Research Article
Document available free of charge
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International Journal of Reproductive BioMedicine, Vol. 18, No. 7, 2020, pp. 531-538
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Effect of tamsulosin on testis histopathology and serum hormones in adult rats: Experimental study
Kohestani, Yegane; Kohestani, Bentolhoda; Shirmohamadi, Zahra & Faghani, Masoumeh
Abstract
Background: Tamsulosin is an inhibitory factor of alpha-adrenergic receptors that is
used for relieving of the clinical symptoms and management of acute urinary retention.
Objective: The aim of this study was to evaluate the effects of tamsulosin on the
endocrine axis and testicular tissue in adult male rats.
Materials and Methods: In this experimental study, 30 adult male Wistar rats (weighing
250-300 gr) were divided into three groups: 1) control (received distilled water), 2)
experimental 1 (received 0.2 mg/kg/day tamsulosin) and 3) experimental 2 (received
0.4 mg/kg/day tamsulosin) through oral gavage for 28 days. Serum hormones level
and testicular histopathology were evaluated at the end of the experiment.
Results: In this study, the testicular weight decreased significantly in the experimental
groups compared to the control group. A significant decrease was seen in testicular
weight (p = 0.004) and the number of Leydig cells in tamsulosin-treated groups (p =
0.012). Tamsulosin improved the hormone profile in experimental groups. Also, higher
dose of tamsulosin significantly changed the number of Leydig, spermatogonia cells,
the thickness of germinal layer, and the diameter of the seminiferous tubules.
Conclusion: Results showed that using tamsulosin, possibly reduces the testosterone
concentration through adrenergic axis system and in turn has destructive effects on
proliferative activity of germ cells.
Keywords
Tamsulosin; Seminiferous tubules; Histopathology; Rat; Testis.
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