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International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433 EISSN: 1680-6433
Vol. 18, No. 9, 2020, pp. 723-732
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Bioline Code: rm20074
Full paper language: English
Document type: Research Article
Document available free of charge
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International Journal of Reproductive BioMedicine, Vol. 18, No. 9, 2020, pp. 723-732
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Effect of embryo transfer depth on IVF/ICSI outcomes: A randomized clinical trial
Davar, Robab; Poormoosavi, Seyedeh Mahsa; Mohseni, Fereshteh & Janati, Sima
Abstract
Background: Although there has been remarkable advancement in the field of assisted
reproductive technology, implantation failure remains a significant issue in most
infertile couples receiving these treatments. Embryo transfer is important in assisted
reproductive technology and directly affects the implantation rates and pregnancy
outcomes.
Objective: To assess the effect of two different distance embryo transfer
sites from fundal endometrial surface on the outcomes of in-vitro fertilization
(IVF)/intracytoplasmic sperm injection (ICSI) cycles.
Materials and Methods: A total of 180 women who were candidate for IVF/ ICSI/
embryo transfer in Yazd Research and Clinical Center for Infertility were equally
assigned to two groups based on the distance between the fundal endometrial surface
and catheter tip to investigate implantation, chemical and clinical pregnancy (group A:
15 ± 5 mm and group B: 25 ± 5 mm, respectively).
Results: The subjects in the group B showed significantly higher implantation rate,
chemical and clinical pregnancy rate compared to the group A (p = 0.03, 0.01, 0.04,
respectively). The rate of ongoing pregnancy and miscarriage indicated no significant
differences between groups (p = 0.21, 0.27, respectively).
Conclusion: In conclusion, our study showed that the depth of embryo replacement
inside the uterine cavity at a distance of 25 ± 5 mm beneath fundal endometrial
surface have better effects on the pregnancy outcomes of IVF/ICSI cycles and can be
considered as an important factor to improve the success of IVF cycles.
Keywords
Embryo transfer; Endometrium; Pregnancy outcomes; IVF; ICSI.
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