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Comparison of the effects of Duphaston and Cetrotide on oocyte and embryo quality in women undergoing ICSI: A cross-sectional study
Motaref, Niloofar; Jouhari, Sheyda; Mohammadzadeh, Afsaneh; Kazemnejad, Somaieh; Madadi, Narges; Eghtedari, Sadaf & Ghoodjani, Abolfazl
Abstract
Background: Premature luteinizing hormone (LH) surge is one of the causes for
assisted reproductive technology cycle cancellation, and it is needed to find novel
approaches with improved efficacy and safety profile.
Objective: To compare the effects of Duphaston and Cetrotide on the prevention of
premature LH surge and characteristics of retrieved follicles and embryos in women
undergoing intracytoplasmic sperm injection.
Materials and Methods: In this retrospective cross-sectional study, 200 patients who
were administrated recombinant follicle-stimulating hormone from the third day of
menstruation cycle were included. When the follicular diameter reached above 13-14
mm, Cetrotide was prescribed in the control group, while in the case group, Duphaston
was taken orally from the third day of cycle. The retrieved oocytes were fertilized in vitro
by intracytoplasmic sperm. The level of hormones on the third day of menstruation and
the characteristic of follicles, oocytes, and embryos were compared between the two
groups.
Results: Duphaston successfully inhibits premature LH surge. There was no significant
difference in the level of follicle-stimulating hormone, estradiol, and LH between the
case and control groups (p > 0.05). However, results also showed that Duphaston
causes more oocyte retrieval in comparison with Cetrotide (p = 0.04). Although, the
number of follicles above 14 mm, mature oocyte, and the total number of viable
embryos in the case group was slightly higher, it did not reach a significant difference
compared with the control group (p > 0.05).
Conclusion: Duphaston could be used as an appropriate medication instead of
gonadotropin-releasing hormone antagonists in women undergoing controlled ovarian
hyperstimulation. Duphaston prescription not only prevents premature LH surge but
also improves the number of retrieved oocytes.
Keywords
Duphaston; Cetrorelix; Dydrogesterone; COH; GnRh antagonis.
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