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Effect of alpha-lipoic acid supplementation on the lipid profile and lipid ratios in women with gestational diabetes mellitus: A clinical trial study
Aslfalah, Hadise; Jamilian, Mehri; Ansarihadipour, Hadi; Abdollahi, Mahdi & Khosrowbeygi, Ali
Abstract
Background: Evidence suggests that Oxidative stress has been shown to plays an
important role in gestational diabetes mellitus (GDM) etiology. On the other hand,
women with GDM are at an increased risk for complications such as endothelial
dysfunction and cardiovascular diseases.
Objective: To investigate the effects of alpha-lipoic acid (ALA) on the maternal
circulating values of lipid profile and lipid ratios in women with GDM.
Materials and Methods: Sixty women with GDM were participated in the present
study. The ALA group (n = 30) received ALA (100 mg/day) and the placebo group
(n = 30) received cellulose acetate (100 mg/day) for eight wk. The maternal circulating
values of hemoglobin A1C, triglyceride (TG), total cholesterol, high-density lipoprotein
cholesterol (HDL-C), low-density lipoprotein cholesterol, triglyceride-glucose (TyG)
index, atherogenic index of plasma (AIP), non-HDL-C, and lipid ratios were assessed
before and after the intervention. P-value < 0.05 was considered as statistically
significant.
Results: The values of TyG index (p < 0.001), TG (p = 0.006), TG/HDL-C (p = 0.003), and
AIP (p = 0.005) decreased significantly in the ALA group after the intervention.
Conclusion: Maternal circulating values of TyG index, TG, TG/HDL, AIP decreased after
eight wk of ALA supplementation in women with GDM.
Keywords
Lipoic acid; Gestational diabetes; Lipids; Triglycerides; Cholesterol.
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