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International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433 EISSN: 1680-6433
Vol. 19, No. 2, 2021, pp. 115-120
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Bioline Code: rm21011
Full paper language: English
Document type: Research Article
Document available free of charge
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International Journal of Reproductive BioMedicine, Vol. 19, No. 2, 2021, pp. 115-120
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Subcutaneous progesterone versus vaginal progesterone for luteal-phase support in frozen-thawed embryo transfer: A cross-sectional study
Aflatoonian, Abbas & Mohammadi, Banafsheh
Abstract
Background: Luteal-phase support is a complex and controversial issue in the field of
reproductive management.
Objective: To compare the safety and efficacy of low-dose subcutaneous progesterone
with the vaginal progesterone for luteal-phase support in patients undergoing rozen-
thawed embryo transfer.
Materials and Methods: In this cross-sectional study, information related to 77 women
that had frozen-thawed embryo transfer was reviewed. The patients were divided into
two groups based on the route of progesterone administration used as a luteal-phase
support. When the endometrial thickness reached ≥ 8 mm, in one group progesterone
(Prolutex) 25 mg/ daily subcutaneous and in another group, vaginal progesterone
(Cyclogest®) 400 mg twice or (Endometrin®) 100 mg thrice daily, were administrated
and continued until menstruation or in case of clinical pregnancy for 8 wk after the
embryo transfer when the fetal heart activity was detected by ultrasonography.
Results: The patient’s characteristics were matched and there was no significant
difference. The chemical and clinical pregnancy rate was higher in the vaginal
progesterone group compared to the prolutex group, but statistically unnoticeable,
(40% vs. 29.6%, p = 0.367) and (28% vs. 22.2%, p = 0.581), respectively.
Conclusion: The findings of this study demonstrate that the new subcutaneous
progesterone can be a good alternative for intramuscular progesterone in women
that dislike and do not accept vaginal formulations as luteal-phase support in assisted
reproductive technology.
Keywords
Progesterone; Subcutaneous; Vaginal; Pregnancy.
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© Copyright 2021 - Aflatoonian et al. Alternative site location: http://www.ijrm.ir
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