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International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433 EISSN: 1680-6433
Vol. 19, No. 3, 2021, pp. 227-234
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Bioline Code: rm21022
Full paper language: English
Document type: Research Article
Document available free of charge
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International Journal of Reproductive BioMedicine, Vol. 19, No. 3, 2021, pp. 227-234
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The exact synchronization timing between the cleavage embryo stage and duration of progesterone therapy-improved pregnancy rates in frozen embryo transfer cycles: A cross-sectional study
Omidi, Marjan; Halvaei, Iman; Akyash, Fatemeh; Khalili, Mohammad Ali; Agha-Rahimi, Azam & Heydari, Leila
Abstract
Background: Synchronization between the embryonic stage and the uterine
endometrial lining is important in the outcomes of the vitrified-warmed embryo transfer
(ET) cycles.
Objective: The aim was to investigate the effect of the exact synchronization between
the cleavage stage of embryos and the duration of progesterone administration on the
improvement of clinical outcomes in frozen embryo transfer (FET) cycles.
Materials and Methods: 312 FET cycles were categorized into two groups: (A) day-3 ET after three days of progesterone administration (n = 177) and (B) day-2 or -4 ET
after three days of progesterone administration (n = 135). Group B was further divided
into two subgroups: B1: day-2 ET cycles, that the stage of embryos were less than
the administrated progesterone and B2: day-4 ET cycles, that the stage of embryos
were more than the administrated progesterone. The clinical outcome measures were
compared between the groups.
Results: The pregnancy outcomes between groups A and B showed a significant
differences in the chemical (40.1% vs 27.4%; p = 0.010) and clinical pregnancies (32.8%
vs 22.2%; p = 0.040), respectively. The rate of miscarriage tended to be higher and live
birth rate tended to be lower in group B than in group A. Also, significantly higher rates
were noted in chemical pregnancy, clinical pregnancy, and live birth in group A when
compared with subgroup B2.
Conclusion: Higher rates of pregnancy and live birth were achieved in day-3 ET after
three days of progesterone administration in FET cycles.
Keywords
Endometrium; Embryo transfer; Pregnancy; Live birth; Progesterone.
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© Copyright 2021 - Omidi et al. Alternative site location: http://www.ijrm.ir
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