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Chronic inflammation in polycystic ovary syndrome: A case–control study using multiple markers
Goswami, Soumik; Choudhuri, Subhadip; Bhattacharya, Basudev; Bhattacharjee, Rana; Roy, Ajitesh; Mukhopadhyay, Satinath; Ghosh, Sujoy & Chowdhury, Subhankar
Abstract
Background: Polycystic ovary syndrome (PCOS) is associated with insulin resistance
and elevated risk of cardiovascular disease and diabetes. Chronic inflammation has
been observed in PCOS in several studies but there is also opposing evidence and a
dearth of research in Indians.
Objective: To estimate chronic inflammation in PCOS and find its relationship with
appropriate anthropometric and biochemical parameters.
Materials and Methods: Chronic inflammation was assessed in 30 women with
PCOS (Group A) and 30 healthy controls (Group B) with highly sensitive C-reactive
protein (hsCRP), interleukin-6 (IL-6), tumour necrosis factor alpha (TNFα), and platelet
microparticles (PMP). In group A, the relationship of chronic inflammation with insulin
resistance, waist hip ratio (WHR) serum testosterone, and serum glutamate pyruvate
transaminase (SGPT) were examined.
Results: In group A, the hsCRP, TNFα, and PMP were significantly elevated
compared to group B. However, IL-6 level was similar between the groups. In group
A, PMP showed a significant positive correlation with waist-hip ratio and serum
testosterone. IL-6 showed a significant positive correlation with insulin sensitivity and
significant negative correlation with insulin resistance and serum glutamate pyruvate
transaminase.
Conclusion: PCOS is associated with chronic inflammation and PMP correlates
positively with central adiposity and biochemical hyperandrogenism in women with
PCOS.
Keywords
Polycystic ovary syndrome; Inflammation; C-reactive protein; Interleukin-6; Tumor necrosis factor; Microparticles.
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