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International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433 EISSN: 1680-6433
Vol. 19, No. 6, 2021, pp. 569-574
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Bioline Code: rm21056
Full paper language: English
Document type: Case Report
Document available free of charge
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International Journal of Reproductive BioMedicine, Vol. 19, No. 6, 2021, pp. 569-574
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Early oocyte triggering followed by in vitro maturation is a good approach in women with resistance ovary syndrome: A case-series
Eftekhar, Maryam; Mohammadi, Banafsheh; Tabibnejad, Nasim & Razi, Mohammad Hossein
Abstract
Background: Some women represent the inability to respond to endogenous
and exogenous gonadotropins during in vitro fertilization/intracytoplasmic sperm
injection cycles leading to the follicular developmental arrest. The women with
resistant ovaries could benefit from in vitro maturation.
Case: This case-series presents pregnancies resulting from initially scheduled
conventional in vitro fertilization which led to arrested cycles because of resistant
ovary syndrome. The protocol was changed to early oocyte triggering for 15 women
due to the small follicles ≤ 12 mm in diameter on day 15 after stimulation with
high doses of exogenous gonadotrophins instead of cycle cancellation. Germinal
vesicle and metaphase I oocytes that were retrieved from follicles were matured in
vitro and inseminated by intracytoplasmic sperm injection. Twenty formed embryos
were transferred on day 3 after oocyte retrieval. This resulted in a 30.76% chemical
pregnancy out of which no abortion occurred. Therefore, we reported a 30.76%
singleton ongoing pregnancy.
Conclusion: It seems that early oocyte triggering followed by in vitro maturation
may be considered as a good modality in women experiencing follicular resistance
to gonadotropins. These cycles can be rescued from cancellation with satisfactory
clinical outcomes.
Keywords
Arrested stimulation cycle; Early oocyte triggering; In vitro maturation; Clinical outcome.
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