en |
Assessment of metabolic syndrome in infertile women with polycystic ovary syndrome in a rural population of South India: A cross-sectional study
Kayali, Sreelalitha; Chitra, Thyagaraju; Kamalanathan, Sadishkumar & Nandeesha, Hanumanthappa
Abstract
Background: Polycystic ovary syndrome (PCOS) is known to be associated with
metabolic syndrome (MS). It is characterised by insulin resistance, hyperinsulinemia,
dyslipidemia, obesity and hypertension. Data related to MS in infertile women with
PCOS are limited in Indian populations.
Objective: This study aims to compare the prevalence of MS in infertile women with
and without PCOS in a rural population in South India.
Materials and Methods: 130 women with PCOS and 130 women without PCOS were
enrolled in this cross-sectional study. A detailed history was taken and a physical
examination was done for all women. Anthropometric parameters, a glucose tolerance
test, fasting glucose / insulin levels, trigylcerides, high-density lipoprotein cholesterol
and blood pressure were assessed in all participants. The International Diabetes
Federation criteria were applied for assessment of MS.
Results: MS was more prevalent in infertile women with PCOS (42.3%) compared
to women without PCOS (19.3%). 56.9% of women with PCOS had low high-density
lipoprotein cholesterol levels, 46.2% had high triglycerides, 71.5% had a high waist
circumference, 31.5% had high blood pressure and 37.7% had high blood glucose levels.
26.0% of the women with PCOS had a healthy weight, and MS was seen in 6.9% of these
women.
Conclusion: The prevalence of MS was higher in women with PCOS in comparison to
women without PCOS. Among the women with PCOS, the prevalence of MS increased
with age (> 27 yr), body mass index and waist circumference (71.5%), and even healthy
women with PCOS contributed to 7% of MS. Hence it becomes necessary to screen all
women with PCOS for metabolic profile risk factors at young age itself to prevent long
term cardiovascular complications.
Keywords
Polycystic ovary syndrome; Metabolic syndrome; Hyperandrogenism; Hormones.
|