Introduction: A great concern exists about the emergence of antibiotic resistant organisms. The goal of this study is to delineate antibiotic sensitivity patterns at King Faisal Hospital.
Methods: A three years study, from Jan 2009 to Dec 2011 was conducted in the Microbiology unit, department of Laboratory, King Faisal hospital, Rwanda. All the specimens and antibiotic sensitivity were processed according to the standard guidelines. Microorganisms and their sensitivity data were reviewed and compiled by using hospital information system.
Results: Over the 3-year period, several
Enterobacteriaceae pathogens declined in susceptibility to various antimicrobial agents. A total of 2153
Enterobacteriaceae were isolated. Most common isolate was
Escherichia coli
(1413) followed by
Klebsiella
species (550),
Enterobacter
species (110),
Proteus
species (165),
Citrobacter
Species (79),
Shigella
species (110) and other species.
Most notable were the decreased sensitivities to cefuroxime:
E. coli (84% to 72%),
Klebsiella (78% to 33%),
Enterobacter (50% to 41%)
Proteus(67% to 59%) and
Shigella to ciprofloxacin (100% to 96%). And also decreased sensitivities to Imipenem:
E. coli (100% to 98%) and
Klebsiella species (100% to 94%).
Conclusion: These decreased antibiotic sensitivities reflect increased bacterial selection pressure as a result of widespread antibiotic use. A combined approach involving infection-control specialists, infectious disease physicians, and hospital administrators is necessary to address this increasingly difficult problem.