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International Journal of Environment Science and Technology
Center for Environment and Energy Research and Studies (CEERS)
ISSN: 1735-1472 EISSN: 1735-1472
Vol. 13, No. 7, 2016, pp. 1833-1838
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Bioline Code: st16171
Full paper language: English
Document type: Short Communication
Document available free of charge
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International Journal of Environment Science and Technology, Vol. 13, No. 7, 2016, pp. 1833-1838
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Studies on an efficient method for determining ethyl carbamate in the workplace air
Kowalska, J. & Jeżewska, A.
Abstract
In relation to the proposal to introduce an
occupational exposure limit value for ethyl carbamate (EC)
in Poland, a need to develop a sensitive method for
determination of this carcinogenic substance in the workplace
air was emerged. In the presented paper, a new
method for its determination by high-performance liquid
chromatography (HPLC) with fluorescence detector (FLD)
is proposed. The method is based on the adsorption of EC
on the cellulose filter, its extraction with water, further
reaction of EC with 9-xanthydrol in acidic solution.
Determination of the obtained EC derivative (N-xanthyl
ethyl carbamate) was then conducted in a reverse-phase
system with acetonitrile and water mobile phase at a flow
rate of 1 mL/min on an Ultra C18 column of 250 mm by
HPLC–FLD. Measurement range of 0.1–2 µg/m3 for a
1440 L of air sample was appropriate to the established
maximum admissible concentration value of 1 µg/m3. The
limit of detection is 0.142 ng/mL, and the limit of quantification
is 0.426 ng/mL, respectively. The developed
quantitative method makes it possible to determine ethyl
carbamate in workplace air, which in turn allows determining
exposure indicators and facilitates occupational risk
assessment for the employees.
Keywords
Ethyl carbamate; Urethane; 9-Xanthydrol; Liquid chromatography; Analytical method; Workplace; Analysis of air
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© Copyright 2016 - Kowalska, J.; Jeżewska, A. Alternative site location: http://www.ijest.org
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