Human African Trypanosomiasis (sleeping sickness) cause considerable mortality and morbidity throughout the world with
Trypansoma brucei
,
T. gambiense and
T. brucei rhodesiense as the major causative agents. The
Terminalia ivorensis
gradient extracts were tested against
T. brucei rhodesiense parasites and the E.D
50 values of 11.11 and 12.32 μg/mL were obtained for the ethyl acetate and ethanolic gradient extracts respectively. The column fractions of the ethyl acetate fraction gave E.D
50 value between 1.98 and 5.46 μg/mL for the very active fractions indicating prospect for the development of potential trypanocidal agent from the plant.
