The antigenotoxic action of a selection of medicinal plants and spices from Morocco including laurel (
Laurus nobilis
), rosemary (
Rosmarinus officinalis
), verbena (
Verbena triphylla
), fenugreek (
Trigonella foenum-graecum
) and nutmeg (
Myristica fragrens
) was assessed using the eye
white/white+ (
w/w+) Somatic Mutation and Recombination Test (SMART) assay of
Drosophila melanogaster
. Methyl methanesulfonate (MMS) was used as a positive mutagenic compound inducing high frequencies of spots in Drosophila larvae. The frequencies of spots per eyes of a treated series are compared to those of its concurrent positive control series using χ
2- test for evaluation of the antigenotoxic effect. The nutmeg at 1% (w/v) demonstrated a marked decrease in MMS-induced spots with an inhibition rate of 50%. Rosemary, fenugreek seeds and laurel showed different inhibition rates with different level of significance.