This study explores the anti-inflammatory and anti-nociceptive activities of
Patrinia villosa
, a Chinese
medicinal plant, and to explore its effects on the proinflammatory cytokines of the rats with pelvic inflammation model. The
animals were randomly divided into
Patrinia villosa group (PV group), dexamethasone group (DEX group), and
model-control group (CON group) to perform an ear edema test, a carrageenin-induced paw edema test, a cotton
pellet-induced granuloma formation test, and an acetic acid-induced writhing test. The model rats with pelvic inflammation
were established, and the serum levels of interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-α)
in each group was detected with the Enzyme-Linked ImmunoSorbent Assay (ELISA). The results of the ear edema test,
carrageenin-induced paw edema test, cotton pellet-induced granuloma formation test, and acetic acid-induced writhing test all
showed that
Patrinia villosa had strong anti-inflammatory and anti-nociceptive effects. In the experiment using model rats
with pelvic inflammation, we found that the serum levels of IL-6, IL-8 and TNF-α in PV and DEX group were all
significantly lower than those of the CON group, and the serum levels of IL-6 and IL-8 in PV group were significantly lower
than those of the DEX group.
Patrinia villosa, with its strong anti-inflammatory and anti-nociceptive activities, can be used
to treat pelvic inflammation and to relieve the associated pain.
