Carpolobia lutea
(G. Don) (Polygalaceae) is a tropical medicinal plant putative in traditional medicines
against gonorrhea, gingivitis, infertility, antiulcer and malaria. The present study evaluated the antimicrobial, antifungal
and antihelicobacter effects of extracts
C. lutea leaf, stem and root. The extracts were examined using the disc-diffusion
and Microplates of 96 wells containing Muller-Hinton methods against some bacterial strains:
Eschericia coli
(ATCC
25922),
E. coli (ATCC10418),
Pseudomonas aeruginosa
(ATCC 27853),
Staphylococcus aureus
(ATCC 25923),
Staphyllococus aureus
(ATCC 6571),
Enterococcus faecalis
(ATCC 29212) and
Bacillus subtilis
(NCTC 8853) and
four clinical isolates: one fungi
(Candida albican
) and three bacteria
(Salmonella
,
Sheigella
and
staphylococcus
aureus). The Gram-positive bacteria:
Staphylococcus aureus (ATCC 25923),
Enterococcus faecalis (ATCC 29212),
Bacillus subtilis (ATCC 19659) and the Gram-negative bacteria:
Escherichia coli (ATCC 25922),
Pseudomonas
aeruginosa (ATCC 27853),
Cândida albicans (ATCC 18804) and
Helicobacter pylori
(ATCC 43504). Some of these
extracts were found to be active against some tested strains but activity against
H. pylori was >1000mg/ml and good
fungistatic activity against
C. albican. The MIC against
C. albican is in the order
n-HF > CHF > ETF= EAF.The order
of potency of fraction was the ethanol root >
n-HF leaf > ethanol fraction stem > chloroform fraction leaf = ethyl
acetate fraction leaf. Polyphenols were demonstrated in ethanol fraction, ethyl acetate fraction, crude ethyl acetate
extract and ethanol extract, respectively. These polyphenols isolated may partly explain and support the use of
C. lutea
for the treatment of infectious diseases in traditional Ibibio medicine of Nigeria.
