The objective of the study was to investigate the
in-vivo anti-tumour activity of
Spica prunellae
extract, and to preliminarily explore the possible mechanism of
in-vivo anti-tumour effect of
Spica prunellae extract. Tumour inhibition rate and tumour apoptosis-related protein status were determined using the mice model of transplanted T lymphoma cell EL-4 tumour, and by immunohistochemical method. The results revealed that
Spica prunellae extract showed certain tumour inhibitory effect, and compared with the model group. Tumour weight in
Spica prunellae high-dose group was highly significantly different (P<0.01). Tumour weight in
Spica prunellae medium-dose group was also significantly different (P<0.05) compared with the model group.
Spica prunellae high-dose group enabled the high expression of Bcl-2 protein (47.54%) and low expression of Bax protein (13.14%). The study concluded that
Spica prunellae extract has certain
in vivo anti-tumour effect, which may be achieved through regulation of apoptosis related proteins.
